By H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Ph.D., Gordon L. Phillips M.D., Gary Van Zant Ph.D. (auth.)
This ebook offers an creation to marrow and peripheral blood stem cellphone transplantation (including twine blood transplants), emphasizing the foundations of this speedily evolving region. a short old point of view is given and the newest advancements are mentioned. specific awareness is given to the explanation and symptoms for transplantation, the choice of donors and resource of stem cells, and the separation, enlargement and manipulation of stem cells. crucial points of histocompatibility, preparative regimens utilized in stem phone transplantation, using hematopoietic development elements and cytokines, the pathophysiology of the graft-versus-host response, and the administration of problems are handled. This e-book should still give you the practising internist, pediatrician, hematologist, and oncologist in addition to different physicians in education or in perform, physicians' assistants, nurses, and scholars with the data essential to comprehend the thoughts of stem mobilephone transplantation and to incorporate transplantation within the therapy making plans quickly after a analysis has been tested. The textual content must also be invaluable to the medical professional who resumes the sufferers' care after they go back from the transplant center.
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Extra resources for A Guide to Blood and Marrow Transplantation
It is unlikely that mouse/human differences in either engraftment kinetics or in the organization of the stem/progenitor cell compartment accounts for the Stem Cell Sources 29 seemingly irreconcilable studies. The history of hematopoietic research shows a remarkable similarity in the two species. Rather, the apparent differences may relate more to the complex nature of the stem/progenitor cell compartment itself. Stem cells are not a homogeneous population but consist of a hierarchy of cells distinguished by prior mitotic history and subtle incremental steps in the process we call differentiation.
In many cases, a potential donor may not feel he or she has any real choice regarding participation in the transplant because it has been taken for granted that they will donate. Such an assumption should not be made; a potential donor who is fully informed and truly does not wish to donate should be firmly supported in this decision. A candid discussion acknowledging the common and at times conflicting emotions reported by donors (such as the chance to help someone else, fear of "failure" of the transplant, sense of responsibility for engraftment and/or GVHD) may help alleviate to some extent the anxiety experienced by donors.
J Clin Oncol9: 1871 Walters MC, Patience M, Leisenring W, Eckman JR, Scott JP, Mentzer WC, Davies SC, Ohene-Frempong K, Bernaudin F, Matthews DC, Storb R, Sullivan KM (1996) Bone marrow transplantation for sickle cell disease. VAN ZANT Since the publication of the last edition of this book in 1992, significant changes have occurred in the procurement of stem cells for transplantation. For example, the standard of care in autologous transplantation has become harvesting stem cells from peripheral blood via leukocytapheresis rather than via bone marrow aspiration.
A Guide to Blood and Marrow Transplantation by H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Ph.D., Gordon L. Phillips M.D., Gary Van Zant Ph.D. (auth.)