By W. Schramm, H. Krebs, S. Fleissner (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)
This booklet includes the contributions to the thirtieth Hemophilia Symposium, 1999. the most subject matters are HIV an infection, inhibitors in hemophilia, smooth remedy of hemophilia, drug-induced thrombophilia and pediatric hemostasiology. the amount is rounded off through quite a few unfastened papers and posters on hemophilia and linked topics.
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Extra resources for 30th Hemophilia Symposium Hamburg 1999
1. State of Research Clinical Aspects of Hemophilia A Hemophilia A is caused by decreased activity of blood coagulation factor VIII. The corresponding gene comprising 26 exons and 186 kb (9 kb coding sequence) is mapped at the X-chromosome (Xq28). Affected individuals develop a variable phenotype of hemorrhage into joints and muscles, easy bruising, and prolonged bleeding from wounds. The disorder is mainly caused by heterogeneous mutations in the F8 gene (for details, see next chapter). The severity and frequency of bleeding in hemophilia A is inversely related to the amount of residual factor VIII ( <2%, severe; 3-5%, moderate; and 6-30%, mild).
Perhaps a prolonged high initial dosage or a combination therapy may have a more pronounced effect and better long-term results. Summary Our preliminary data of the high-dosage treatment with interferon show that the virus load of HCV-RNA could be reduced in all patients by 80%. HCV-RNA disappeared transiently in 6 out of 14 patients during 12 weeks, but a high recurrence has to be considered in most of the patients. A sustained response could be ob- 34 R. Zimmermann et al. served in 2 (14%) of our patients.
32:98-112. 7. , and R. Esteban. 1999. Retreatment of interferon relapse patients with chronic hepatitis C. JHepatol. 31 Suppll:174-7. 8. Choo, Q. , G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a eDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 244:359-362. Current Therapy of Hepatitis C Virus Infection 31 9. Diepolder, H. , J. T. Gerlach, R. Zachoval, R. M. Hoffmann, M. C. lung, E. A. Wierenga, S. Scholz, T. Santantonio, M.
30th Hemophilia Symposium Hamburg 1999 by W. Schramm, H. Krebs, S. Fleissner (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)